Endocrine Abstracts

Introduction: Preserving of C-peptide secretion in type 1 diabetes mellitus (DM1) is an important goal in treatment, as it provides the possibility of optimal compensation. Various approaches are used to achieve this goal. We initiated a study to assess the potential effect of the cell therapy based on autologous Tolerogenic Dendritic Cells on the newly diagnosed DM1 (NCT05207995, ClinicalTrials.gov).Methods: 4 patients who were injected with Tolerogenic...

Introduction: Preserving of C-peptide secretion in type 1 diabetes mellitus (DM1) is an important goal in treatment, as it provides the possibility of optimal compensation. We initiated a study (ClinicalTrials.gov 26.01.2022, NCT05207995) to assess the potential effect of Tolerant Dendritic Cells (tolDC) on the newly diagnosed DM1.Methods: Evaluation of stimulated C-peptide against the background of a standard breakfast (carbohydrate content of 50g) was ...